Fri. Jan 15th, 2021

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Gilead Announces Results From Phase 3 Trial

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Gilead Sciences announced top line results from the open-label, Phase 3 SIMPLE trial evaluating 5-day and 10-day dosing duration of the investigational antiviral remdesivir in hospitalized patients with severe manifestations of COVID-19 disease.

The study demonstrated that patients receiving a 10-day treatment course of remdesivir achieved similar improvement in clinical status compared with those taking a 5-day treatment course (Odds Ratio: 0.75 [95% CI 0.51 – 1.12] on Day 14).

No new safety signals were identified with remdesivir across either treatment group. Gilead plans to submit the full data for publication in a peer-reviewed journal in the coming weeks.

“Unlike traditional drug development, we are attempting to evaluate an investigational agent alongside an evolving global pandemic. Multiple concurrent studies are helping inform whether remdesivir is a safe and effective treatment for COVID-19 and how to best utilize the drug,” said Merdad Parsey, MD, PhD, Chief Medical Officer, Gilead Sciences.

 

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